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Description

4-MPrC hydrochloride (4-methylphenylpropan-2-amine) represents a Premium Analytical Reference standard from the important chemical class of Phenylethylamine. This molecule is structurally related to numerous forensically relevant stimulants, making it an indispensable reference in forensic science. Toxicological and forensic analysis represents. Its specific molecular signature enables precise calibration and differentiation in the context of the constantly evolving new psychoactive substances (NPS).

The distribution of this 4-MPrC Standards is strictly regulated and takes place exclusively for controlled, scientific purposes on qualified experts in authorized and accredited research institutions. We guarantee a analytically confirmed purity of 98% of the hydrochloride salt, the fundamental prerequisite for the Validity and Reproducibility your highly sensitive chromatographic and spectroscopic Measurements. For laboratories that need a reliable Phenylethylamine control standard or 4-MPrC reference material we provide the basis for the highest scientific and legal standards.

 Analytical excellence: chemical specifications and quality assurance at the highest level

The integrity of the reference material is the cornerstone of any valid analytical method. The precise characterization of 4-MPrC is crucial for the differentiation of isomers and structural analogues, which are often characterized by only minimal substitution differences.

Detailed chemical characterization and material properties

4-MPrC belongs to the class of Phenylethylamine, whose basic structure consists of a phenyl ring and an ethylamine chain. The methyl substitution in the 4-position of the phenyl ring is responsible for the specific chemical and metabolic properties of the molecule and must be precisely verified analytically.

• Chemical class: Substituted phenylethylamines.
• Nomenclature: 4-Methylphenylpropan-2-amine (as hydrochloride salt).
• Molecular weight: Crucial for the gravimetric and volumetric preparation of standard solutions.
• Formulation: Is available as a stable Hydrochloride salt which results in an increased Durability and good solubility in polar solvents (methanol, aqueous buffers) for LC-MS/MS-assays are guaranteed.
• Aggregate state: High purity, crystalline powder, optimized for precise gravimetric weighing according to ISO 17025 regulations.

Guaranteed purity and documentation for laboratories

Our commitment to the purity of 98% is ensured by redundant, analytical methods that meet the requirements for GLP and ISO 17025 exceed.

1. Primary purity confirmation: The purity is primarily determined by means of HPLC (High-Performance Liquid Chromatography) quantified with photometric detection (UV/DAD). This ensures that all volatile and non-volatile impurities are precisely detected.
2. Secondary molecular identification: The molecular identity is confirmed by at least two independent methods: Gas chromatography-mass spectrometry (GC/MS) and Liquid chromatography-tandem mass spectrometry (LC-MS/MS). The characteristic fragment ions and spectral signatures are essential for the creation of forensic databases.
3. Comprehensive certificate of analysis (CoA): Each batch contains a detailed CoA, spectral data, the purity evaluation and the Traceability of the synthesis batch.
4. Batch consistency: Thanks to standardized production and cleaning processes, we guarantee a minimum of waste. Batch variability, which is responsible for the Long-term validation and the Validity of measurements across different reference points is crucial.

 Central fields of application in research and analytics

4-MPrC hydrochloride is a fundamental reagent for laboratories dealing with the Metabolism and the Development of analytical methods for synthetic stimulants.

Forensic toxicology, calibration and quality control

The standard is essential for laboratories that analyze samples in critical cases (e.g. traffic toxicology, post-mortem analyses).

• Method validation: The standard is used for Validation from LC-MS/MS and GC-MS Methods for safe Identification and Quantification of phenylethylamines in biological samples. The determination of the Selectivity (compared to isomers) and the Matrix effects is of paramount importance here.
• Calibration: The high-purity material is used to create precise, linear Calibration curves which is the basis for the accurate determination of concentrations in the low nanogram range in forensic matrices.
• Device tuning and QC: 4-MPrC serves as Reference point for the daily tuning and Performance check of the sensitive mass spectrometers and as a positive control standard in routine measurements.

Pharmacological and metabolic research (further studies)

The research utilizes 4-MPrC to investigate the effects of 4-methyl substitution on the pharmacological profile compared to other phenylethylamines.

• Neurotransmitter studies: Molecular research investigates the Affinity and Potency on Dopamine, noradrenaline and serotonin transporters for modeling the in silico and in vitro pharmacological activity.
• Metabolism identification: Through comprehensive In vitro-Studies (e.g. using recombinant P450 enzymes), all primary and secondary Metabolites of 4-MPrC were identified and their structure confirmed. The precise knowledge of these metabolite profiles is essential for the forensic detectability of the substance, even long after consumption.

 Legal framework and laboratory safety

The acquisition and handling of this controlled research chemicals are subject to the strictest regulations and are reserved exclusively for scientific research.

Regulatory compliance and responsibility

As 4-MPrC is recognized in many jurisdictions as a controlled substance (e.g. under the NpSG), distribution is highly regulated.

• Exclusively research: Sales are strictly limited to the Analysis and research in authorized scientific institutions restricted. Any other use is not permitted.
• Buyer obligation: The buyer assumes full responsibility for compliance with all local and international laws regarding the import, possession and use of controlled chemicals.

Safety protocols for laboratory users

Strict compliance with the Material Safety Data Sheet (MSDS) is mandatory.

• PSA: Lab coat, safety goggles and chemical resistant Gloves are obligatory.
• Working environment: Powder handling and solution preparation must be carried out under certified fume cupboard systems take place.
• Storage: Cool (2-8 °C), dry and protected from lightin order to analytical stability to ensure that.

 Acquisition of the 4-MPrC reference standard

We offer 4-MPrC hydrochloride in the following analytically relevant quantities: 100 mg (reference sample), 500 mg and 1 g.

Order requirements:

1. Proof of the Authorization of the research institution.
2. Written confirmation that the substance exclusively for analytical reference purposes is used.
3. Recognition of the Limitations of liability and the MSDS.

For secure, legally compliant and fast ordering of your 4-MPrC reference standards to guarantee the Validity of your analytical methods, please contact us directly.