Buy Alpha-PVT online

Description

Alpha-PVT hydrochloride (Alpha-pyrrolidinopentiothiophenone) is not just another standard; it is a Premium Analytical Reference Standard The latest generation of the method, which has been specially developed to improve the validity and reliability of methods in the critical areas of forensic Toxicology and the chemical analysis from new psychoactive substances (NPS) to maximize the benefits. The unique Thiophene-based structure, in which the phenyl ring is replaced by a thiophene unit, makes alpha-PVT an indispensable Control molecule for the Structure-activity relationship (SAR) research within the Cathinon family.

The distribution of this Alpha-PVT Standards takes place for strictly scientific purposes only on qualified experts and Accredited research institutions. We guarantee a analytically confirmed purity of  98% of the hydrochloride salt, a purity that exceeds standard requirements and precise, traceable and reproducible Measurement results in the Mass spectrometry and Chromatography secures. If your laboratory has a Thiophene-cathinone reference standard, Alpha-PVT control material or Analytical reagents for drug analysis This product is the basis for legally usable analyses and scientific excellence.

 Analytical excellence: chemical specifications and quality assurance at the highest level

The integrity of the reference material is the cornerstone of any analytical method. Alpha-PVT requires utmost care during characterization and storage due to its complex molecular architecture and susceptibility to oxidative degradation.

Detailed chemical characterization of alpha-Pyrrolidinopentiothiophenone

Alpha-PVT belongs to the structural group of substituted cathinones and is characterized by the beta-keto structure and the Pyrrolidine group characterized. The substitution of the phenyl ring by the Thiophene unit causes a significant shift in the chromatographic behavior (retention time) and in the spectroscopic properties, which is essential for the Differentiation of isomers is.

• Chemical class: Thiophene-based alpha-Pyrrolidinophenone (Cathinone).
• Alternative designations: alpha-pyrrolidinopentiothiophenone.
• Structure profile: Contains a Thiophene unit on the aromatics and a Pyrrolidine group at the alpha-position of the ethylamine chain.
• Formulation: As a stable Hydrochloride salt which provides improved durability and good solubility in polar solvents (methanol, acetonitrile) and aqueous buffer solutions for LC-MS/MS-assays.
• Aggregate state: High purity, crystalline powder, which is optimized for precise gravimetric standard preparation in accordance with ISO regulations.

Guaranteed purity through multi-analytical verification

Our commitment to the purity of 98% is ensured by redundant, analytical methods that meet the requirements for GLP and ISO 17025 not just meet, but exceed them.

1. Primary purity confirmation: The purity is primarily determined by means of HPLC (High-Performance Liquid Chromatography) quantified with photometric detection (UV/DAD). This ensures that all volatile and non-volatile impurities are precisely detected.
2. Secondary molecular identification: The molecular identity is confirmed by at least two orthogonal methods: Gas chromatography-mass spectrometry (GC/MS) and/or Liquid chromatography-tandem mass spectrometry (LC-MS/MS). This spectral data is essential for the creation of forensic databases.
3. Comprehensive certificate of analysis (CoA): Each batch contains a detailed CoA, spectral data (incl. characteristic fragment ions), the purity evaluation and the Traceability of the synthesis charge.
4. Stability guarantee: The analytical stability is maximized by specific storage guidelines and formulation as a hydrochloride salt to ensure the integrity of the standard over the entire shelf life.

Extended areas of application in forensics and pharmacology

Alpha-PVT is a critical control molecule for understanding the toxicology of synthetic stimulants, particularly those with structural deviations from the classical phenethylamine backbone.

Forensic toxicology, calibration and quality control

The Alpha-PVT standard is fundamental for the forensic analysis of samples in critical cases (e.g. road traffic, overdoses, post-mortem analyses).

• Method validation: The standard is indispensable for the development and Validation from Multi-target screening assays for the reliable detection of alpha-pyrrolidinophenone derivatives. This includes the determination of Selectivity (compared to matrices and isomers) and the Matrix effects.
• Calibration and quantification: The high-purity material is used to create precise, linear Calibration curves is used. This is the basis for the precise determination of concentrations in the low nanogram range in biological samples - a requirement for forensic evidence.
• Device tuning: Alpha-PVT serves as Reference point for daily tuning and performance testing of the sensitive mass spectrometers.

Pharmacology and metabolism research

The research focuses on how thiophene substitution affects the Pharmacodynamics and the Metabolism compared to benzene analogs.

• Neurotransmitter studies: Molecular research investigates the Affinity and Potency of the molecule on dopamine, noradrenaline and serotonin transporters. These data are essential for predicting the toxicological risk.
• Metabolism identification: Through comprehensive In vitro-Studies (e.g. using recombinant P450 enzymes), all primary and secondary Metabolites of alpha-PVT were identified and their structure confirmed. The provision of these metabolite profiles is key to the forensic detectability of the substance, even long after exposure.

 Legal framework, laboratory safety and reference information

The acquisition and handling of this controlled research chemicals are subject to the strictest regulations.

Regulatory compliance and responsibility

As Alpha-PVT is recognized in many jurisdictions as a controlled substance (e.g. under the NpSG), distribution is highly regulated.

• Exclusively research: Sales are strictly limited to the Analysis and research in authorized scientific institutions restricted. Any other use is inadmissible and prohibited.
• Buyer obligation: The buyer is obliged to full compliance all local, national and international laws with regard to the import, possession and use of controlled chemicals.

Required safety protocols and storage

Strict compliance with the Material Safety Data Sheet (MSDS) is essential to protect laboratory staff and ensure the stability of the standard.

• PSA: Lab coat, safety goggles and chemical resistant Gloves are obligatory.
• Working environment: Powder handling must be carried out under certified fume cupboard systems take place.
• Storage: Cool (2-8 °C), dry and protected from lightin order to analytical stability of the standard.

 Purchase and ordering requirements

We offer alpha-PVT hydrochloride in the following quantities 100 mg (reference sample), 500 mg and 1 g to.

Mandatory order requirements:

1. Proof of the Authorization of the research institution.
2. Written confirmation that the substance exclusively for analytical reference purposes is used.
3. Recognition of the Limitations of liability and the MSDS.

For secure, legally compliant and fast ordering of your Alpha-PVT reference standards to guarantee the Validity of your analytical methods, please contact us directly.